A blog covering the health/care ecosystem and people.

People want to make health with their health care providers, and they want more than care from them: most patients are looking for support with healthy eating, exercise, emotional support, sleep, stress management, social relationships, and financial health. And in case physicians, nurses and pharmacists aren’t sufficiently business with that punch-list for health, two in three U.S. patients would also like to receive help in finding a higher purpose. This is the health consumer’s mass call-out for holistic health, Welltok discovered in a survey conducted among over 1,600 U.S. adults in March 2019. The results are detailed in the assertively 

The supply side of digital health tools and tech is growing at a hockey-stick pace. There are mobile apps and remote health monitors, digital therapeutics and wearable tech from head-to-toe. Today in America, electronic health records (EHRs) are implemented in most physician offices and virtually all hospitals. Chapter 5 of my book, HealthConsuming: From Health Consumer to Health Citizen, details the promise of digital health: wearable, shareable and virtual. Today, we can also call on Alexa to remind us to take medications, play nostalgic music when we are lonely, check our physical activity status with Fitbit, and query WebMD about

We are all Homo informaticus these days, multi-channel, multi-platform beings using digital platforms. “Computing is not about computers anymore. It is about living,” Nicholas Negroponte wrote in Being Digital. He said that in 1995. In that quarter-century since Negroponte made that prescient observation, we come to better understand that being a Digital Society has its upsides and downfalls, alike. We need a “new needs model” for the digital age, asserts a new report, Human Needs in a Digital World, the 2019 Digital Society Index report from the Dentsu Aegis network. Taking Maslow’s Hierarchy of Needs as a basic construct, the Index

“The Fourth Industrial Age,” Dr. Abraham Verghese writes, “has great potential to help, but also to harm, to exaggerate the profound gap that already exists between those who have much and those who have less each passing year.” Dr. Verghese asserts this in his forward to Deep Medicine, Dr. Eric Topol’s latest work which explores the promise of artificial intelligence (AI), Big Data, and robotics — three legs of the Fourth Industrial Age stool. [If you don’t know the work of Dr. Verghese, and since you’re reading the Health Populi blog, you must get to know Dr. V now. Your

When you think “genomics,” your mind probably pictures a human DNA strand. Well, my mind did, prior to meeting with Dr. Joseph Frassica and Dr. Felix Baader at HIMSS19 to discuss Philips’ approach to the tragic problem of healthcare-acquired infections that kill patients. Ever since that conversation, my mind’s eye is filled with images of MRSA cells like those shown here. At HIMSS19, Philips launched a solution that couples clinical informatics with genomic sequencing of bacteria to quickly identify and treat patients that are affected with tough-to-treat infections that, so often, result in death. Healthcare-acquired infections (HAIs) are a worldwide

“The promise of AI is undeniable…could AI help clinicians deliver better and more humanistic care?” This question is asked and answered in a JAMA viewpoint published January 1/8 2019 titled, Humanizing Artificial Intelligence. This theme motivated a conversation held over a dinner convened by Philips hosted by Frans Van Houten this week at HIMSS19. To provide context Geoff Colvin, Fortune‘s Senior Editor, first talked about taking friction out of industries, as Lyft and Uber have done in the transport sector. “Taking friction out of industries challenges and changes business models,” Geoff noted. With Uber’s IPO valuation approaching $100 billion, I’d say that’s

Self-care is the new health care as patients, now consumers at greater financial risk for medical spending, are learning. At #CES2019, I’m on the lookout for digital technologies that can help people adopt and sustain healthy behaviors that can help consumers save money on medical care and enhance quality of life-years. This week’s heart-and-food tech announcements at #CES2019 coincide with an FDA recall on a popular drug prescribed to treat hypertension (high blood pressure). Using food and tech as medicine can help people avoid going on medications like statins and others for heart health. An important example of this self-care

Today is Boxing Day and St. Stephens Day for people who celebrate Christmas, so I share this post as a holiday gift with well-wishes for you and those you love. The tea leaves have been brewing here at THINK-Health as we prepared our 2019 forecast at the convergence of consumers, health, and technology. Here’s our trend-weaving of 4 C’s for 2019: costs, consumerism, cyber and care, everywhere… Health care costs will continue to be a mainstream pocketbook issue for patients and caregivers, with consequences for payors, suppliers and ultimately, policymakers. Legislators inside the DC Beltway will be challenged by the

The future of healthcare is not about being sick, Prof. Dr. Koen Kas believes. Having spent many years in life sciences in both research and as an entrepreneur, Koen now knows that getting and staying healthy isn’t about just developing medicines and med-tech: optimally, health requires a tincture of delight, Koen advises in his breakthrough, innovative book, Your Guide to Delight. Healthcare must go beyond traditional user-centered design, Koen’s experience has shown, and aspire toward design-to-delight. The concept of “delight” in healthcare, such as we experience in hospitality, grocery stores, and entertainment, is elusive. I’ve observed this, too, in my

Information is power in the hands of people. When it’s open in the sunshine, it empowers people — whether doctors, patients, researchers, Presidents, teachers, students, Everyday People. Welcome to the era of Open Source Healthcare, not only the “about time” for patients to own their health, but for the launch of a new publication that will support and continue to evolve the concept. It’s really a movement that’s already in process.     Let’s go back to some definitions and healthcare basics to understand just why Open Source Healthcare is already a thing. When information access is uneven, it’s considered

In our Amazon-Primed world, the future of retail is not ten years from now; it’s “tomorrow.” So GMDC, the association of retailers and brands who supply them, has formed a program called Retail Tomorrow to turbocharge the supply side with consumers who are already demanding convenience, immediate (or “soon”) gratification, and health where she/he “is.” That’s personalization, and that’s where retail health can and is making a difference in Everyday Peoples’ lives. In our DIY culture, we’re pumping our own petrol, making our own airline and hospitality reservations (from Expedia to Airbnb), trading stocks online, and cooking at home enabled by

Googling the words “disruption” and “healthcare” today yielded 33.8 million responses, starting with “Riding the Disruption Wave in Healthcare” from Bain in Forbes, Accenture’s essay on “Big Bang Disruption in Healthcare,” and, “A Cry for Encouraging Disruption” in the New England Journal of Medicine Catalyst. This last article responded to the question, “Can we successfully deliver better quality care for patients at a lower cost?” asked by François de Brantes, Executive Director of the Health Care Incentives Improvement Institute. “Disruption” as a noun and an elephant in our room has been with us in healthcare since the September/October 2000 issue of

With the vast majority of patients’ medical records now digitized in electronic health records systems, the opportunities to mine, learn from, and act on the findings are promising for U.S. healthcare. More data is moving into internet clouds every day, from healthcare encounters with clinicians and inpatient hospital stays to prescribed medicines, retail receipts for over-the-counter remedies, wearable technologies, credit card swipes for products and services, and GPS check-ins. That’s a treasure trove of digital footprints that can tell a lot about us as patients, either in real-time or via prediction. But can we nudge stakeholders in health and healthcare

Most Americans say that pharmaceutical manufacturers, banks, advertisers, energy firms, and tech companies have too much power and influence in today’s American economy, according to Public Attitudes Toward Technology Companies, a research report from the Pew Research Center. A plurality of Americans says labor unions and farming and agriculture have too little power, along with a majority of people who believe that small business lacks sufficient power in the current U.S. economy. This data point is part of a larger consumer survey on Americans’ attitudes about the growing role of technology in society, particularly with respect to political and social impacts.

When it comes to healthcare costs, lines that decline over time are generally seen as good news. That’s how media outlets will cover the top-line of PwC’s report Medical cost trend: Behind the numbers 2019. However, there are other forces underneath the stable-looking 6.0% medical trend growth projected for 2019 that will impact healthcare providers, insurers, and suppliers to the industry. There’s this macro-health economic story, and then there’s the micro-economics of healthcare for the household. Simply put: the impact of growing financial risk for healthcare costs will be felt by patients/consumers themselves. I’ve curated the four charts from the

“Do no harm” has been the professional and ethical mantra of physicians since the Hippocratic Oath was first uttered by medical students. The origins of that three-word objective probably came out of Hippocrates’ Corpus, which included a few additional words: “to do good or to do no harm.” The proliferation and evolution of digital technologies in health care have the potential to do good or harm, depending on their application. Doing good and abstaining from doing harm can engender trust between patients, providers, and other stakeholders in health. Trust has become a key currency in provider/patient/supplier relationships: 94% of health executives

When you’re on the battlefield and you can’t see what lies ahead, go high, recommended General Von Clausewitz in his book, On War. I paraphrase this prescription from the good General-strategist’s book, On War — “War is the realm of uncertainty; three-quarters of the factors on which action in war is based are wrapped in a fog of greater or lesser uncertainty. A sensitive and discriminating judgment is called for; a skilled intelligence to scent out the truth.” Governor Mark Leavitt, who held the post of Secretary of Health and Human Services under President Bush, offered this advice at the recent Liberation

“Health agencies will have to become at least as sophisticated as other consumer/retail industries in analyzing a variety of data that helps uncover root causes of human behavior,” Gartner recommended in 2017. That’s because “health” is not all pre-determined by our parent-given genetics. Health is determined by many factors in our own hands, and in forces around us: physical environment, built environment, and public policy. These are the social determinants of health, but knowing them even for the N of 1 patient isn’t quite enough to help the healthcare industry move the needle on outcomes and costs. We need to

Trust in the United States has declined to its lowest level since the Edelman Trust Barometer has conducted its annual survey among U.S. adults. Welcome to America in Crisis, as Edelman brands Brand USA in 2018. In the 2018 Edelman Trust Barometer, across the 28 nations polled, trust among the “informed public” in the U.S. “plunged,” as Edelman describes it, by 23 points to 45. The Trust Index in America is now #28 of 28 countries surveyed (that is, rock bottom), dropping below Russia and South Africa. “The public’s confidence in the traditional structures of American leadership is now fully

Journalists and industry analysts from around the globe have come to Las Vegas which, this week, is the mecca for new-new electronic things that companies think consumers will be keen to buy. On media day 1, I spoke with a colleague from the Netherlands who covers audio, a sector that’s certainly in disruption; an automotive analyst from India covering autonomous vehicles; and, a mobile tech guru based in Dubai, to identify just a few of my media friends who have gathered here to research and write on their respective beats. In these conversations, there are some common buzzwords floating around

Yesterday, the FDA approved a “digital ingestion tracking system,” the first drug in the U.S. that has an ingestible (in other words, safely edible) sensor built into the pill. That sensor tracks that the medication was taken, which helps with adherence, meant to help ensure that patients who are prescribed the medicine do indeed take the regimen as prescribed. Once ingested, the sensor in the pill communicates to a wearable patch on the patient that then communicates information to a mobile health app that tracks the pill-taking via smartphone. Patients can allow their family and clinicians access to that information

  A response to Amazon’s potential moves in healthcare and pharmacy…strategic positioning for the post-Trump healthcare landscape…vertical integration to better manage healthcare utilization and costs…these, and other rationale have been offered by industry analysts and observers of the discussions between CVS and Aetna, for the former to acquire the latter. “A pharmacy chain buying a health insurance company?” many have asked me over the past few days. These inquiring minds include people who work both inside and outside of health/care. I ask back: in 2017 and in the future, “What is a pharmacy? What is a health plan?” See the

Fast Company’s October 2017 issue leads with a cover story featuring Microsoft’s CEO Satya Nadella, with the title, “Microsoft Rewrites the Code.” The issue of Fast.Co is devoted to the theme of innovation by design, and the 8-page story on the company emphasizes the themes of empathy and collaboration in re-imagining the organization. I lead with this because I’m now in Orlando preparing to participate in Microsoft’s annual meeting called Envision. This conference brings together the company’s clients from around the world, representing major industry segments. I’m grateful to be invited to participate in the first of six sessions devoted

        Between 2012 and 2017, the number of US consumers who shopped online for health insurance grew by three times, from 14% to 42%, according to a survey from Connecture. Cost first, then “keeping my doctor,” are the two top considerations when shopping for health insurance. 71% of consumers would consider switching their doctor(s) to save on plan costs. Beyond clinician cost, health plans shoppers are also concerned with prescription drug costs in supporting their decisions. 80% of consumers would be willing to talk with their doctors about prescription drug alternatives, looking for a balance between convenience

Technology should serve people, and Accenture has identified five major key trends that, together, could forge a person-centered, -friendly, -empowering healthcare system. This is Accenture’s Digital Health Technology Vision for 2017. “Should” and “could” are the important adverbs here, because if tech doesn’t deliver, driving efficiency and effectiveness, personalizing medical treatments, and inspiring people to become more health literate and health-engaging, then tech is just a Field of Dreams being built and available, with no people taking advantage of the potential benefits. The five new-new tech trends are: AI is the new UI, where healthcare experience is everything Ecosystem power

“Helping people on their path to better health” is the mission-mantra of CVS Health. Re-branded from its previous identity as CVS/pharmacy, the organization convened a Health Innovation Summit with its vendor partners whose products fill the front-of-store shelves to empower, inspire and support consumers to manage health and wellness for themselves and their families. I was grateful for the opportunity to provide the first talk for the day, setting the context for the evolving retail health/care landscape with the consumer at the center. The consumer is, at any point in a 24-hour day: a person wearing many hats (a worker,

“What doctor?” asks the title of a PwC report on the emergence of artificial intelligence (AI) and robotics in healthcare. AI and robot technology are penetrating all aspects of the macroeconomy, and they’ve begun to re-shape the health economy, as well. Underneath PwC’s titular question are two lenses: the role of the AI/robot doctor vis-a-vis the role of the human doctor. PwC identifies eight areas that AI and robotics will impact in healthcare, shown in the first diagram: Decision making Diagnosis Early detection End of life care Keeping well Research Training, and Treatment. For keeping well, AI and robotics can

The truest form of health reform and consumer-directed health care isn’t in a high-deductible health plan or a health savings account, and it doesn’t come out of Washington DC or your employer’s health benefits office. It comes from you in the form of self-care and DIY healthcare. In this case, think “inspired by sport, powered by you.” I’ll be participating on a panel at this weekend’s South-by-Southwest Festival in Austin, Texas, along with three wellness innovators: Nick Buettner of the Blue Zones project, Mary Liz McCurdy of Google, and John Wilbanks from Sage Bionetworks. Together, our quartet will brainstorm the

The autonomous car is a metaphor for healthcare: that’s how my first interview kicking off the  HIMSS marathon began. The annual 2017 HIMSS conference isn’t your father’s or mother’s HIMSS of ten years ago, or even the HIMSS of 2010 — the year that financial incentives for EHR adoption began to stream from the HITECH Act of 2009, motivating thousands of healthcare providers to acquire and meaningfully use digital health records systems. Then, the HIMSS conference floor was abuzz with EHR frenzy. This week, over 43,000 people working at the intersection of healthcare and technology have converged in Orlando, Florida, for

A special report on patient engagement and digital technology was published this month in the New England Journal of Medicine (NEJM). Based on a survey of doctors and healthcare executives, the research found that clinicians and managers welcome the opportunity to use digital tech — when it makes financial sense. That conclusion inspired the title of the article, Patient Engagement Survey: Technology Tools Gain Support – But Cost Is a Hurdle. NEJM polled 595 members of the NEJM Catalyst Insights Council, which included healthcare executives and clinicians who deliver healthcare. Here is NEJM’s scenario on patient-engaging health IT, a Holy Grail of sorts:

Health citizens in America will need to be even more mindful, critical, and engaged healthcare consumers in 2017 based on several factors shaping the market; among these driving forces, the election of Donald Trump for U.S. president, the uncertain future of the Affordable Care Act and health insurance, emerging technologies, and peoples’ growing demand for convenience and self-service in daily life. The patient is increasingly the payor in healthcare. Bearing more first-dollar costs through high-deductible health plans and growing out-of-pocket spending for prescription drugs and other patient-facing goods and services, we’re seeking greater transparency regarding availability, cost and quality of

Technology is high on U.S. consumers’ holiday shopping lists for the 2016 holiday season, according to the CTA (Consumer Technology Association). And wearable activity trackers are a fast-growing segment of consumer technology purchases expected in shoppers’ carts (both physical and online virtual) this fourth quarter of 2016, CTA notes in its 23rd Annual Holiday Outlook consumer survey research. The line graph illustrates the hot categories in this year’s holiday gift mix, led by smart phones (in red), tablets, laptops, and video game systems. But the proportion of people intending to purchase smartwatches now ties with video game system sales, closely followed

When a person dons a piece of wearable technology, they first look to engage with some aspect of health or fitness before they seek entertainment. To satisfy that demand side of the market equation, we’re seeing a stream of devices, platforms, and corporate strategies trying to reach the wearable tech consumer. Today, Philips announced its expanding strategy for digital health, launching devices to help people, in Philips’ words, measure, monitor, and stay motivated for personal health. The company is offering a health smartwatch, a weight scale, an ear thermometer, and two blood pressure monitors (for wrist and upper arm), all

There’s a lot of talk about the growing platform economy. If well-designed platforms get adopted in healthcare, they may help our ailing healthcare systems get better. The quality, safety, and convenience of healthcare in America suffer from a lack of patients’ personal health data being essentially locked in data siloes. The diagnosis is lack of data “liquidity:” the ability for our health information generated in various touch points in the healthcare system and in our personal lives each day to move outside of the locations where the bits and bytes were first created: to our clinicians, researchers, health providers, and to

Nearly 1 in 2 people own at least one wearable device, up from 21% in 2014; one-third of people own more than one such device that tracks some aspect of everyday life, according to PwC’s latest research on the topic, The Wearable Life 2.0 – Connected living in a wearable world, from PwC. Wearable technology in this report is defined as accessories and clothing incorporating computer and advanced electronic technologies, such as fitness trackers, smart glasses (e.g., Google Glass), smartwatches, and smart clothing. Specifically, 45% of people own a fitness band, such as a Fitbit, the most popular device in this

The first health news I read this morning in my Google Alerts was a press release explaining that Nokia planned to acquire Withings for EU170 (about $190mm). As an early adopter and devoted user of the Withings Smart Body Analyzer, I took this news quite personally. “What will Nokia be doing with my beloved Withings?” I asked myself via Twitter early this morning. As if on cue, a public relations pro with whom I’ve been collegial for many years contacted me to see if I’d like to talk with the Founder and CEO of Withings, Cédric Hutchings, and Ramzi Haidamus,

Faxing in health care ranks higher in patient data information sharing than using secure email, online portals, health information exchange (HIE), or leveraging electronic health records. Welcome to the American healthcare system in 2016, as described in a market spotlight published by IDC, The Rocky Road to Information Sharing in the Health System. IDC’s survey research among healthcare providers forecasts the “rocky road” to information sharing. That rocky road is built for medical errors, duplication of services, greater healthcare costs, and continued health il-literacy for many patients. “The holy grail of interoperability — lower-cost, better-quality care with an improved experience for

Adoption of telehealth, remote health monitoring, patient engagement platforms, mobile and digital health applications, and the emergence of the Internet of Things in health care will all be bolstered in 2016 based on health care providers’ having to do more with less (money, labor, resources). The value-based healthcare world — the migration of payment “from volume to value” — requires greater investment in information and communications technology that moves care to lower-cost sites, with lower-priced labor (as appropriate), and shifting greater clinical self-care and financial skin-in-the-game to patients. My annual health IT forecast was published yesterday in iHealthBeat, 2016: Technology

Sales of computers and tablets and LCD TVs won’t be hot on peoples’ holiday shopping lists in 2015. But smartwatches, health and fitness tech, and 4K Ultra HD TVs will be in peoples’ gift wish-lists and under homes’ holiday trees. The Consumer Electronics Association (CEA) published its 2015 U.S. Consumer Electronics Sales and Forecasts report, and it shows a shifting retail picture where traditional consumer electronics categories — notably computers and mainstream TVs — are declining in demand. But new-new categories are expected to buoy 2015 retail sales. The new categories of consumer electronics will generate about $10 bn (wholesale

We’re entering the era of personalized healthcare promising convenient and meaningful health experiences, according to Accenture’s 2015 Healthcare IT Vision articulated in their report, Top 5 eHealth Trends. This post is third in three published here on Health Populi this week, exploring the growing role of the Internet of Things in health/care. On 8th July, we dug into McKinsey Global Institute’s research on IoT’s influence over nine industries, including human health; and on the 9th, we reviewed Goldman Sachs’ report on digital health’s potential impact on the U.S. healthcare system. Accenture’s five eHealth trends include: The Internet of Me; the Outcome Economy, with

‘Tis the summer of big, smart reports covering the Internet of Things (IoT) impact on health and fitness. Just this month, three of these missives have come to my inbox, and they all contribute sound thinking about the topic. Today, tomorrow and Friday, I’ll cover each of these here in Health Populi. We begin with McKinsey Global Institute’s The Internet of Things: Mapping the Value Beyond the Hype. [In full disclosure, I was an outside adviser to the MGI team members who focused on the human/health and fitness aspects of this report, and thank MGI for the opportunity to provide

Two forces are converging to shape a new era of “living services,” Accenture posits: the digitization of “everything” and consumers’ “liquid” expectations — which are demands for personalized, engaging and adaptable experiences. Accenture’s report on this phenomenon, The Era of Living Services, spans the broad range of consumers’ daily lives where these services will impact: homes, families, transportation, shopping, leisure time, jobs, finances, education, cities, and above all for Health Populi readers, “our bodies.” Living services are physically close to us, as Accenture sees them, “wrapping themselves around the everyday things we do.” They are digital services that are aware

In recent weeks, an enormous amount of money has been raised by organizations using information technology to move health/care to people where they live, work, and play… This prompted one questioner at the recent ANIA annual conference to ask me after my keynote speech on the new health economy, “Is the hospital going the way of the dinosaur?” Before we get to the issue of possible extinction of inpatient care, let’s start with the big picture on digital health investment for the first quarter of 2015. Some $429 mm was raised for digital health in the first quarter of 2015,

Alex Gourley, President of The Walgreen Company, addressed the capacity crowd at HIMSS15 in Chicago on 13th April 2015, saying his company’s goal is to “make good health easier.” Remember that HIMSS is the “Health Information and Management Systems Society” — in short, the mammoth health IT conference that this year has attracted over 41,000 health computerfolk from around the world. So what’s a nice pharmacy like you, Walgreens, doing in a Place like McCormick amidst 1,200+ health/tech vendors?  If you believe that health is a product of lifstyle behaviors at least as much as health “care” services (what our

They’re the team that built a brand with the phrase “Health 2.0” before the world barely recognized v 1.0 in healthcare. This week, those folks that brought you the Health 2.0 Conference unveiled the Market Intel database of over 3,000 companies, trying to make sense out of a very blurry and fast-morphing market landscape. I spoke with Matthew Holt and Kim Krueger of Health 2.0 earlier this week to discuss just what’s in this mine of information, and what they intend to do with it. In full disclosure, I have been a colleague and friend of Matthew Holt since his

Three laws that shape the digital world have kicked into high gear, changing our lives in ways we cannot yet imagine. Those three forces are Metcalfe’s Law (in brief, the increasing value of networks), Moore’s Law (that processing power doubles every 18 months, or even faster), and the Law of Accelerating Returns (the fast pace of technological change). The guy who told me about that at the 2015 Consumer Electronics Show (#CES2015) was Shelly Palmer, something of a Renaissance Man in the evolving digital world, advising communications companies, composing music, patenting TV technology, investing in ventures, hosting shows on digital living,

Mobile and digital technologies will bend the health care cost curve, drive individual and population health, and solve the nagging challenge of health disparities. Mobile and digital technologies will increase costs to health providers, disrupt work flows and lower clinicians’ productivity, and hit a market bubble. Depending on your lens into mHealth, and what product categories and user segments you’re looking at, all of the above can be true. The plenary session of the 2014 mHeath Summit kicked off with Dr. Harry Leider, Chief Medical Information Officer of Walgreens, who spoke of the pharmacy’s evolving role across the entire continuum of care,

Dr. Joseph Kvedar has led the Center for Connected Health for as long as I’ve used the word “telehealth” in my work – over 20 years. After two decades, the Center and other pioneers in connected health have evidence proving the benefits, ROI (“hard” in terms of dollars, and “soft” in terms of patient and physician satisfaction), and technology efficacy for connecting health. The 11th Annual Connected Health Symposium is taking place as I write this post at the Seaport Hotel in Boston, bringing health providers, payers, plans and researchers together to share best practices, learnings and evidence supporting the

Moore’s Law is coming to medicine. And it will look and feel a lot like Uber: with rich technology underpinning,  consumer-service oriented and friendly, and shaking up the professionals at the front line of the business (from taxi drivers to physicians). Eric Topol, physician and editor-in-chief at Medscape, told a standing-room-only audience at the kickoff of the 8th annual Health 2.0 Conference that the democratization of health care is coming based on consumers’ use of eight drivers: sensors, labs, imaging, physical exams, access to medical records, transparency of costs, and digital pills. Dr. Topol referred to the cover ot TIME